Naurex Inc. Reports Positive Top-Line Phase I Results For Its Novel Mechanism NMDA Receptor Modulator GLYX-13 In Treatment-Resistant Depression
Naurex Inc., a clinical stage company developing innovative treatments for depression and other CNS disorders based on its novel glycine site functional partial agonist (GFPA) NMDA receptor modulators, today reported positive top-line results from its Phase I clinical trial of lead compound GLYX-13. GLYX-13 is a GFPA selective modulator of the NMDA receptor. It is initially being developed as a therapy for treatment-resistant depression in severely depressed patients. In the Phase I trial, adverse events were similar for subjects receiving GLYX-13 and placebo and were all rated as mild. There were no signs of the schizophrenia-like side effects associated with other NMDA receptor modulator drugs.
Many clinicians believe that depression goes hand in hand with cognitive difficulties such as memory problems or difficulties concentrating and paying attention, but a recent review of nearly 20 years of literature conducted by researchers from UT Southwestern Medical Center has found that depression does not always lead to such impairments. "The relationship between cognition thinking, attention and memory and depression remains poorly understood from a neuroscientific standpoint, " said Dr. Munro Cullum, chief of psychology at UT Southwestern and senior author of the review appearing in the January issue of Neuropsychology, a journal published by the American Psychological Association.
Meg McArthur, from Breakthrough Breast Cancer, says: "This research is welcome because it gives an insight into how the effectiveness of tamoxifen could be influenced by taking antidepressants. Tamoxifen remains a beneficial treatment for breast cancer and as several antidepressants are available doctors should be able to find the right combination for patients. "This should not put patients off taking tamoxifen and any concerns should be discussed with their doctor." Source Breakthrough Breast Cancer
One of many reasons that attendance at Alcoholics Anonymous (AA) meetings helps people with alcohol use disorders stay sober appears to be alleviation of depression. A team of researchers has found that study participants who attended AA meetings more frequently had fewer symptoms of depression - along with less drinking - than did those with less AA participation. The report will appear in the journal Addiction and has been release online. "Our study is one of the first to examine the mechanisms underlying behavioral change with AA and to find that AA attendance alleviates depression symptoms, " says study leader John F. Kelly, PhD, associate director of the Massachusetts General Hospital (MGH) Center for Addiction Medicine.
Although children can be depressed for many reasons, new evidence suggests that there are physiological differences among depressed children based on their experiences of abuse before age 5. Early abuse may be especially damaging due to the very young age at which it occurs. Those are the findings of a new study of low-income children that was conducted by researchers at the University of Minnesota and the University of Rochester, Mt. Hope Family Center. The study appears in the January/February 2010 issue of the journal Child Development. Children who experience maltreatment, including physical, sexual, and emotional abuse or neglect, grow up with a lot of stress.
People with anxiety and depression are most likely to use a shade of gray to represent their mental state. Researchers writing in the open access journal BMC Medical Research Methodology describe the development of a color chart, The Manchester Color Wheel, which can be used to study people's preferred pigment in relation to their state of mind. Peter Whorwell, Professor of Medicine and Gastroenterology at University Hospital South Manchester, worked with a team of researchers from the University of Manchester, UK, to create an instrument that would allow people a choice of colors in response to questions. He said, "Colors are frequently used to describe emotions, such as being 'green with envy' or 'in the blues'.
Children from urban areas whose mothers suffer from depression during pregnancy are more likely than others to show antisocial behavior, including violent behavior, later in life. Furthermore, women who are aggressive and disruptive in their own teen years are more likely to become depressed in pregnancy, so that the moms' history predicts their own children's antisocial behavior. That's the conclusion of a new longitudinal study conducted by researchers at Cardiff University, King's College London, and the University of Bristol. The research appears in the January/February 2010 issue of the journal Child Development. The study considered the role of mothers' depression during pregnancy by looking at 120 British youth from inner-city areas.
Depression raises risks of advanced and severe complications from diabetes, according to a prospective study of Group Health primary-care patients in western Washington. These complications include kidney failure or blindness, the result of small vessel damage, as well as major vessel problems leading to heart attack or stroke. The findings were published this week in Diabetes Care, a scientific journal of the American Diabetes Association. The study was conducted by scientists from the Group Health Research Institute, Seattle; the University of Washington (UW) School of Medicine and School of Public Health, and the Veterans Affairs Puget Sound Health Care System.
Adolescents with suicidal thoughts and elevated depression had stronger and faster reduction of symptoms when treated with family therapy than with standard treatment in the community. Researchers from The Children's Hospital of Philadelphia reported these findings this month in the Journal of the American Academy of Child and Adolescent Psychiatry. Suicide is the third leading cause of death in American adolescents, accounting for more than 1, 300 deaths in youths between the ages of 12 and 18 in 2005. An additional one million teens attempt suicide each year, leading to high emotional and financial costs to families and the health care system. Unfortunately, very few treatment studies have focused on this vulnerable age group or identified treatments with proven results.
Scientists at Emory University School of Medicine have discovered unexpected properties for a precursor to melatonin, the hormone that regulates sleep cycles. Melatonin is produced from the neurotransmitter serotonin in a daily rhythm that peaks at night. Melatonin's immediate precursor, N-acetylserotonin, was not previously thought to have effects separate from those of melatonin or serotonin. Now an Emory team has shown that N-acetylserotonin can stimulate the same circuits in the brain activated by the growth factor BDNF (brain-derived neurotrophic factor). The results will be published online this week in the Proceedings of the National Academy of Sciences.