Breast cancer patients treated with the chemotherapy drug Taxol (paclitaxel) are more likely to develop chronic neuropathic pain, according to research published in The Journal of Pain, the peer review publication of the American Pain Society. Researchers from the University of Texas MD Anderson Cancer Center conducted a survey of breast cancer patients who participated in clinical trials of Taxol from 1994 to 2001. There were 240 respondents. The purpose of the study was to determine the association between chemotherapy-induced peripheral neuropathy (CIPN) and neuropathic pain in breast cancer patients treated with Taxol. The authors noted that few studies have examined the extent to which breast cancer survivors who experience CIPN during chemotherapy go on to develop chronic neuropathic pain.
Caldolor R Ibuprofen Injection Demonstrates Significant Fever Reduction In Hospitalized Burn Patients
Cumberland Pharmaceuticals Inc. ( CPIX) announced positive new top-line results from a study evaluating the safety and efficacy of Caldolor ( ibuprofen ) Injection in treating fever in hospitalized burn patients. Statistical significance was achieved for the primary endpoint of reducing fever in burn patients over the first 24 hours of treatment. The study evaluated 61 adult burn patients with second or third degree burns covering more than 10 percent total body surface area. Other participant criteria included an anticipated hospital stay of more than 72 hours and temperatures of 38.0 degrees C (100.4 degrees F) or greater. Patients were administered 800mg of Caldolor every six hours for five consecutive days.
French Study Is First To Associate Pain Assessment With Improved Outcomes In Mechanically Ventilated ICU Patients
A large study of more than 1, 300 patients has provided evidence that increased attention to pain assessment in mechanically ventilated patients in the intensive care unit (ICU) may improve patient outcomes and lead to shorter ICU stays. According to lead study author Jean-Francois Payen, M.D., Ph.D., of the Hopital Albert Michallon in Grenoble, France, pain assessment and management can often be an underappreciated aspect of care that may improve care during and after an ICU stay. "Despite the existence of clinical scoring systems to quantify pain in verbal and nonverbal patients, routine clinical practice seldom applies them, " said Dr. Payen. "Through the results of our research, though, we demonstrate that pain assessment must be promoted together with sedation measurements to improve patient outcomes.
Cervical spondylosis is a general term for age-related wear and tear affecting the joints in the neck. It is also known as cervical osteoarthritis and degenerative osteoarthritis. This condition usually appears in men and women older than 40 and progresses with age. Men usually develop it at an earlier age than women do. It can lead to episodes of stiffness and neck pain. With age, the bones and cartilage that make up the backbone and neck gradually deteriorate. Sometimes there is formation of irregular bony outgrowths called bone spurs. These changes are characteristic of cervical spondylosis. Even so, many people with signs of cervical spondylosis on X-rays manage to escape the associated symptoms, which include pain, stiffness and muscle spasms.
Charcot-Marie-Tooth Disease (CMT), also known as Chacot-Marie-Tooth hereditary neuropathy, peroneal muscular atrophy, and hereditary motor and sensory neuropathy, is a genetic disease of nerves, typically with progressive muscle weakness, particularly the arms and legs. The hallmark feature of CMT is a clear wasting of the distal extremities, especially the peroneal muscle groups in the calves - the patient develops stork legs. In most cases, patients experience weakening of the legs before the arms. Two French neurologists, Jean Charcot (1825-1893), Pierre Marie (1853-1940), and the English physician Howard Henry Tooth (1856-1925) were the first to fully clinically describe the disease;
Older adults who reported chronic musculoskeletal pain in two or more locations, higher levels of severe pain, or pain that interfered with daily activities were more likely to experience a fall than adults who did not reports these types of pain, according to a study in the November 25 issue of JAMA. "Falls rank among the 10 leading causes of death in older adults in the United States, resulting in more than $19 billion in health care costs annually. Despite a growing body of scientific evidence supporting associations between a number of risk factors and falls, efforts to translate these findings into effective fall prevention strategies have been limited, " the authors write.
Headaches and heartaches. Broken bones and broken spirits. Hurting bodies and hurt feelings. We often use the same words to describe physical and mental pain. Over-the-counter pain relieving drugs have long been used to alleviate physical pain, while a host of other medications have been employed in the treatment of depression and anxiety. But is it possible that a common painkiller could serve double duty, easing not just the physical pains of sore joints and headaches, but also the pain of social rejection? A research team led by psychologist C. Nathan DeWall of the University of Kentucky College of Arts and Sciences Department of Psychology has uncovered evidence indicating that acetaminophen (the active ingredient in Tylenol) may blunt social pain.
Chronic pain is experienced by as many as two out of three older adults. Now, a new study finds that pain may be more hazardous than previously thought, contributing to an increased risk of falls in adults over age 70. The findings appear in the November 25 issue of The Journal of the American Medical Association (JAMA). "It's clear that pain is not just a normal part of aging and that pain is often undertreated in older adults, " explains lead author Suzanne Leveille, PhD, RN, who conducted the research while a member of the Division of Primary Care at Beth Israel Deaconess Medical Center (BIDMC) and is currently on the faculty at the University of Massachusetts Boston.
Athletes' superstitions and rituals can help them get psyched up for contests, but when these rituals involve non-steroidal anti-inflammatory drugs (NSAIDs), which many athletes gobble down before and during events, they could be causing more harm than good. "These agents are treatments for the symptoms of an injury, not the injury itself, " says Stuart Warden, whose research at Indiana University focuses on musculoskeletal health and sports medicine. "They may allow an athlete to exercise or train at a certain level, but pain occurs for a reason. It is basically the body's mechanism of saying, 'Hang on, you've got some sort of injury that should not be ignored.
Chilblains or chilblain are small, itchy swellings on the skin, which are not painful at first, but can become painful. This inflammation of small blood vessels in the skin is also known as pernio and perniosis. It is a localized form of vasculitis in reaction to sudden warming from cold temperatures. The itching, swelling and blistering red patches are located on extremities, such as toes, fingers, ears and nose. Chilblains usually respond well to treatment and clear up within 14 days. Treatments normally consist of lotions and medication. While it does not usually result in permanent injury, chilblains can lead to severe damage if left untreated. The best approach to chilblains is to avoid developing it by limiting exposure to cold, dressing warmly and covering exposed skin.